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Institute Research Scientist -Immuno-oncology
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Education
Required: Bachelor's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
Preferred: PhD degree in immuno-oncology, cancer immunology or related field.
Experience
Required: Ten years of relevant research laboratory experience. With Master's degree, eight years of required experience and with PhD, two years of required experience.
Preferred: Four years Industry experience.
1. Experience in a pharmaceutical/biotech environment.
2. Evidence of multi-color flow-cytometry analysis of tumor infiltrates, circulating
immune populations and lymphatic populations is highly preferred. Experience
with in vitro analysis of immune cells will also be valued. Demonstration of
hypothesis driven research in in vitro and in vivo models of immunooncology/
checkpoint blockade is preferred.
3. Experience with experimental design, project planning and working in the context of timelines and deliverables is preferred. Application of relevant expertise in the areas of immuno-oncology to project goals will be valued. The ability to plan,execute and interpret experimental data in a timely fashion is essential. The ability to prioritize and manage multiple experiments in a timely and resource effective manner for enablement of science-based go/no-go decision making is also essential
4. Demonstrate a deep understanding of both human and murine immunology
pertaining to maturation, signaling pathways, tumor infiltration, functional immune compartments, and/or knowledge of tumor microenvironment and its impact on the immune system.
5. Proactively implement in vitro and in in vivo immunologic assays for evaluating activity and mechanism of action of immuno-oncology drug candidates using key immune cell populations.
6. Drive understanding of mechanism of action, and biology of response for targets of interest with a focus on immuno-oncology related targets and outcomes.
7. Independently propose innovative solutions to research projects and contribute to project goals through laboratory experiments while defining the immune-related mechanisms of action of small molecules under development in the IACS/CCCT pipeline.
8. Work closely with research teams to experimentally interrogate hypotheses around developmental targets in the context of the immuno-oncology to further advance scientific discovery and clinical therapeutic drug development; including, but not limited to, genetic and pharmacological validation of targets, identification of proximal and distal biomarkers, utilization of syngeneic and humanized mouse models to drive drug discovery and clinical path development.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Required: Bachelor's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
Preferred: PhD degree in immuno-oncology, cancer immunology or related field.
Experience
Required: Ten years of relevant research laboratory experience. With Master's degree, eight years of required experience and with PhD, two years of required experience.
Preferred: Four years Industry experience.
1. Experience in a pharmaceutical/biotech environment.
2. Evidence of multi-color flow-cytometry analysis of tumor infiltrates, circulating
immune populations and lymphatic populations is highly preferred. Experience
with in vitro analysis of immune cells will also be valued. Demonstration of
hypothesis driven research in in vitro and in vivo models of immunooncology/
checkpoint blockade is preferred.
3. Experience with experimental design, project planning and working in the context of timelines and deliverables is preferred. Application of relevant expertise in the areas of immuno-oncology to project goals will be valued. The ability to plan,execute and interpret experimental data in a timely fashion is essential. The ability to prioritize and manage multiple experiments in a timely and resource effective manner for enablement of science-based go/no-go decision making is also essential
4. Demonstrate a deep understanding of both human and murine immunology
pertaining to maturation, signaling pathways, tumor infiltration, functional immune compartments, and/or knowledge of tumor microenvironment and its impact on the immune system.
5. Proactively implement in vitro and in in vivo immunologic assays for evaluating activity and mechanism of action of immuno-oncology drug candidates using key immune cell populations.
6. Drive understanding of mechanism of action, and biology of response for targets of interest with a focus on immuno-oncology related targets and outcomes.
7. Independently propose innovative solutions to research projects and contribute to project goals through laboratory experiments while defining the immune-related mechanisms of action of small molecules under development in the IACS/CCCT pipeline.
8. Work closely with research teams to experimentally interrogate hypotheses around developmental targets in the context of the immuno-oncology to further advance scientific discovery and clinical therapeutic drug development; including, but not limited to, genetic and pharmacological validation of targets, identification of proximal and distal biomarkers, utilization of syngeneic and humanized mouse models to drive drug discovery and clinical path development.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
