🌎
This job posting isn't available in all website languages

Settings

(While navigating through the site, please be sure to disable your pop-up blocker.)


Institute Research Investigator - Target Discovery and Validation

📁
Research
💼
Therapeutics Discovery 710621
📅
115567 Requisition #
Apply for Job
Share this Job
Sign Up for Job Alerts
MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner. 


The Institute Research Investigator - Target Discovery and Validation participates in cross-functional research to identify and validate novel oncology targets, and translate these finding into novel oncology therapeutic agents to benefit patients.

Salary Range Min $85,000 - Mid $106,250 - Max $127,500


KEY FUNCTIONS

1. Independently proposes innovative solutions to research projects and contributes to project goals through laboratory experiments. 
2. Assists in the application and development of cutting edge tools and methodologies to analyze data generated by various studies.
3. Assist in the integration of data to identify genes/pathways pertinent to tumor development and treatment.
4. Works closely with research team to identify and recommend opportunities leading to the discovery of tumor related genes/pathways to further advance scientific discovery and clinical therapeutic drug development.
5. Designs and provides proof of concept for assays that will be used to drive small molecule development.
6. Adapt to new technologies and find solutions to related program studies.
7. Perform common tissue culture techniques including viral transduction utilizing cDNA/RNAi/CRISPR technologies to answer biology questions
8. Demonstrate knowledge of complex culture systems including stem cell, co-culture systems, primary tumor cells from clinical or preclinical tumors.
9. Utilize common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (i.e., site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies.
10. Apply vivo models to advance programs including subcutaneous and orthotopic xenografts or genetically engineered models of cancer.
11. Develop and utilize molecular (i.e. Immunofluorescence, live imaging, ELISA, Western, etc.) and/or functional (i.e. soft agar, migration, invasion, proliferation, etc.) cell bases assays.
12. Utilize siRNA, inducible shRNA, dominant negative methods, and small molecule inhibitors to validate targets and biomarkers.
13. Interpret, present and report research findings at internal meetings and to senior leadership.
14. Design and guide the activities of other scientists to maximize productivity and impact.
15. Employ safe lab practices.
16. Maintain research records and laboratory notes.

Education
Required: Bachelor's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.  

Preferred: Master's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.  

Experience
Required: Six years experience of relevant research experience in lab. With preferred degree, four years of required experience. 


Preferred: Experience with common tissue culture techniques including viral transduction and DNA/siRNA transfection to generate stable cell lines; experience with complex culture systems including stem cell, co-culture systems, primary tumor cells from clinical or preclinical tumors; common molecular biology skills including Western, ELISA, RNA quantification methods (Q-PCR), DNA cloning (i.e., site directed mutagenesis, protein tagging, shRNA design and validation) and characterization of commercial/custom antibodies; experience (or willingness to work) with vivo models including subcutaneous and orthotopic xenografts or genetically engineered models of cancer; previous experience dosing animals; and, experience developing and utilizing molecular (i.e., Immunofluorescence,  live imaging, ELISA, Western, etc.) and/or functional  (i.e., soft agar, migration, invasion, proliferation, etc.) cell based assays are strongly preferred. Experience using siRNA, inducible shRNA, dominant negative methods to validate targets; as well as experience with utilizing small molecule inhibitors for target and biomarker validation are preferred.  The position requires a highly self-motivated individual, with outstanding organizational skills, the ability to effectively present results and conclusions to co-workers, collaborators and manager. Ability to work well under pressure and drive personal and team objectives that impact critical timelines is expected. A collaborative attitude is essential for this position.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

SONJ

My Submissions

Track your opportunities.

My Submissions

Similar Listings

Pathology/Lab Medicine - Resch 900042

United States, Texas, Houston, Houston (TX Med Ctr)

📁 Research

Requisition #: 119760

Therapeutics Discovery 710621

United States, Texas, Houston, Houston (TX Med Ctr)

📁 Research

Requisition #: 118466

Diagnostic Imaging - Research 900095

United States, Texas, Houston, Houston (TX Med Ctr)

📁 Research

Requisition #: 116632