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Institute Associate Scientist IV - Medicinal Chemistry

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Research
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Therapeutics Discovery 710621
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120257 Requisition #
MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.

We are seeking a highly motivated Master Degree scientist to join our team of scientists within MD Anderson Cancer Center's Institute for Applied Cancer Science working towards the discovery of novel anti-cancer compounds for the treatment of targeted patient populations.

The Associate IV, Medicinal Chemistry will be responsible for innovative research in the the discovery and development of novel small molecule oncology agents. He/She will be will be responsible for the design and synthetic execution of small molecules targets to advance IACS oncology drug discovery projects. By liaising with other members of the IACS medicinal chemistry team, this individual will play a key role in the identification and optimization of the next generation of cancer therapeutics.  

The ideal candidate will have Master's degree in Chemistry with expert knowledge in synthetic organic chemistry, several years organic chemistry laboratory experience, with demonstrated ability to conduct challenging multi-step organic chemistry synthesis and overcome synthetic hurdles. Experience in the medicinal chemistry field acquired in pharma or biotech environment and understanding of the drug discovery process will be a plus. Demonstrated team-player who possesses excellent problem solving capabilities, and can contribute independently to the success of the project.

Key Functions:

1. Independently propose innovative solutions to research projects, and contribute to project goals through laboratory experiments.

2. Contribute to the design and synthesis of small molecule modulators of protein targets through lab based activities.

3. Work closely with research team and contribute to the identifation and development of new target molecules with improved potency, selectivity, functional activity on their protein target and ADME properties.

4. Propose new target molecules, designs synthetic routes and executes the synthesis thereof. Trouble shoot synthetic issues with his / her synthetic targets.

5. Leverage latest synthetic approaches, parallel MedChem and purification techniques.

6. Contribute patent filing in order secure the intellectual property rights for novel small molecules.

7. Interact across cross-functional groups, liase with members of the computational chemistry, structural biology and in vitro pharmacology teams. 

8. Employ safe lab practices.

9. Maintain research records and laboratory notes.

Education
Required: Bachelor's degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field. 

Preferred: Master's degree in organic chemistry or medicinal chemistry.

Experience
Required: Five years of relevant research experience in lab. With preferred degree, three years of required experience. 

Preferred: Experience in pharma or biotech company.

The ideal candidate will have Master's degree in Chemistry with expert knowledge in synthetic organic chemistry, several years organic chemistry laboratory experience, with demonstrated ability to conduct challenging multi-step organic chemistry synthesis and overcome synthetic hurdles. Experience in the medicinal chemistry field acquired in pharma or biotech environment and understanding of the drug discovery process will be a plus. Demonstrated team-player who possesses excellent problem solving capabilities, and can contribute independently to the success of the project.


It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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