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Institute Associate Scientist II
MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson's top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner.
The Institute for Applied Cancer Science is seeking a highly motivated and team oriented individual to be join our ADME/PK research group to support the Institute for Applied Cancer Sciences fast-paced drug discovery programs. The position requires a high self-motivated individual, with organizational skills, and the ability to effectively present results and conclusions to co-workers and managers. A collaborative attitude is essential for this position.
The ideal candidate will have experience in ADME assays using liver microsomes and/or hepatocytes and have experience in metabolite identification and structural elucidation using high resolution mass spectrometers. He/She will be familiar with using automation for sample processing, and skilled in analysis using triple quadrupole and high-resolution LC-MS/MS instruments.
He/She will have good communication skills and will regular liaise with other members of the cross-functional project team. This individual will be a key contributor in the identification and optimization of the next generation of cancer therapeutics.
Key Functions
* Under moderate supervision, executes in vitro ADME assays on drug discovery programs, such as liver microsomal and hepatocytic stability assays, kinetic solubility, and plasma protein binding assays etc.
* Under moderate supervision, maintain cell culture and conduct MDCK cell permeability assay.
* Under guidance, develop, validate, and execute new ADME/PK assays as needed.
* Conduct analytical method development, validation, and qualification for a large variety of small molecules. Quantify analytes in various biological matrices using triple quadrupole LC-MS/MS.
* Help to maintain and troubleshoot triple quadrupole LC-MS/MS systems.
* Participate in integrated drug discovery research project teams and interacts across cross-functional groups, liaise with members of the medicinal chemistry, in vitro & in vivo pharmacology, and biology teams.
* Employ safe lab practice.
* Maintain research records and laboratory notes.
Core Competencies
Self-Motivation (Transitional): Set high standards of performance; pursue goals with energy and persistence; drive for results and achievement.
Demonstrate a personal sense of urgency in getting results. Use personal and management standards to complete assignments.
Seek to influence standards with proven business practices. Improve own performance by making specific changes in system or work methods.
Self-Adaptability (Transitional): Work in situations involving uncertainty, shifting priorities, and rapid change; deal constructively with mistakes and setbacks; demonstrate flexibility.
Help coworkers with tasks as necessary. Smoothly handle multiple demands, shifting priorities and rapid change. Persist despite obstacles.
Change own immediate behavior or approach to suit the situation. Remain open-minded and adjust approach on basis of new information.
Technical/Functional Expertise (Independent Contributor): Demonstrate technical proficiency required to do the job; possess up-to-date knowledge in the profession; provide technical expertise to others.
Apply basic technical/functional knowledge to complete work. Meet essential position requirements.
Seek experiences and knowledge in technical/functional areas to gain additional expertise. Troubleshoot systems/processes effectively.
Analytical Thinking (Transitional): Gather relevant information systematically; break down problems into simple components; make sound decisions.
* Identify relationships among a few parts of a problem. Scan own knowledge and experience base to determine potential solutions.
* See multiple relationships among several parts of a problem. Recognize likely causes of events or consequences of actions. Use data from multiple sources to support assumptions.
Team with Others (Independent Contributor): Encourage collaboration and input from all team members; value the contributions of all team members, and those beyond team; balance individual and team goals.
* Support and show respect to team members. Recognize how individual actions affect the team.
* Model team qualities i.e. respect helpfulness and coping. Support team decisions once they are made and help to implement.
Working Conditions
Office environment
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This position requires: |
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Working in Office Environment |
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__X_ Yes |
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Working in Patient Care Unit (e.g. Nursing unit; outpatient clinic) |
_X_ No |
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Exposure to human/animal blood, body fluids, or tissues |
__X__No |
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Exposure to harmful chemicals |
__X__No |
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Exposure to radiation |
_X_ No |
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Physical Demands
Indicate the time required to do each of the following physical demands:
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Time Spent |
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Never 0% |
Occasionally 1-33% |
Frequently 34-66% |
Continuously 67-100% |
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Standing |
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Walking |
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Sitting |
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Reaching |
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Lifting/Carrying |
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Up to 10 lbs |
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10lbs to 50 lbs |
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More than 50 lbs |
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Pushing/Pulling |
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Up to 10 lbs |
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10lbs to 50 lbs |
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More than 50 lbs |
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Use computer/keyboard |
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EDUCATION:
Required: Bachelor's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field.
Preferred: Master's degree in Biology, Biochemistry, Molecular Biology, Cell Biology, Enzymology, Pharmacology, Chemistry or related field. One year of relevant research experience in lab. With preferred degree, no required experience.
EXPERIENCE:
Required: Three years of relevant research laboratory work. With Master’s degree, one year of required experience.
Preferred:
Experience in pharma or Biotech Company.
The ideal candidate will have experience in ADME assays using biomatrix such as liver microsomes and hepatocytes, working on plasma and tumor tissue PK or PD samples, using automation and SPE (solid phase extraction) for sample processing, and analyzing samples using LC-MS/MS instruments. Demonstrated team player who possesses excellent problem solving capabilities, and can contribute independently to the success of the project.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
